This database was constructed to serve as a centralized, comprehensive, and readily accessible source of data concerned with the body burden among humans of xenobiotics. Such a database served to alert the scientific community to the need for measuring exposures to specific chemicals and to identify those chemicals for which toxicological and carcinogenic studies should be carried out. Two files were contained in the database: chemicals identified in human biological media and chemicals identified in feral and food animals. Approximately 65 periodicals were searched manually for current data to be included in the system. Information on body burdens in animals was also included in the base for animals occupy a spot in the human food chain, they provide early warning signs of human exposures, and they may alert humans to potential hazards as specific doses which may cause various effects among animals may have no effect on humans. Over 16,000 records were contained in the base. Information contained included bibliographic data elements, language of original article, CAS registry number and preferred name, synonyms, chemical formula and properties, sources of chemical exposure, routes of exposure, animal species examined, number or cases, concentration points within the body, suitable analytical techniques for measuring levels, half life, demography, toxicity, health effects, pathology, morphology, explanatory comments, and keywords.
Proceedings of the Fourth NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, April 22-23, 1986, Rockville, Maryland, NIH Publication No. 88-2960