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Biochemical, Pharmacological and Tumorigenic Studies on a Composite of Drinking Water Carcinogens and Mutagens Utilizing Aquatic Animals.
Overstreet-RM; Hawkins-WE; Walker-WW
This study was performed to determine the different reactions of various fish to carcinogenic compounds, to demonstrate the wide variety of neoplasms which can develop in fish, to demonstrate that a combination of halomethanes can induce neoplasia in fish, and to show the effect of the genotoxic compound methylazoxymethanol- acetate (592621) (MAM-Ac) in a model. Fish used in the study included the Japanese-medaka, king-cobra-guppy, sheepshead-minnow, Gulf-killifish, inland-silverside, rivulus, and fathead-minnow. The chemicals used in the study included a mixture of six trihalomethanes (THM), specifically chloroform (67663), bromodichloromethane (75274), chlorodibromomethane (124481), bromoform (75252), trichloroethylene (79016), and carbon- tetrachloride (56235). Also included were the following single compounds: vinylidene-chloride (75354), trichloroethylene, and bis(2-chloroethyl)ether (111444). The authors conclude that some small aquarium fish are good carcinogenicity models as they are sensitive to induction of a wide variety of neoplasms which have a short latency period. The fish also have a low number of spontaneous neoplasms, are cheap to maintain, and most susceptible tissues can be screened for neoplasms in one or a few microscopic slides.
Carcinogens; Chlorinated-hydrocarbons; Mutagens; Halogenated-hydrocarbons; Environmental-contamination; Animal-studies; Halogenated-compounds; Methanes;
592-62-1; 67-66-3; 75-27-4; 124-48-1; 75-25-2; 79-01-6; 56-23-5; 75-35-4; 111-44-4;
Proceedings of the Fourth NCI/EPA/NIOSH Collaborative Workshop: Progress on Joint Environmental and Occupational Cancer Studies, April 22-23, 1986, Rockville, Maryland, NIH Publication No. 88-2960
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division