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Teratogenicity of n-propanol and isopropanol administered at high inhalation concentrations to rats.
Nelson BK; Brightwell WS; MacKenzie Taylor DR; Khan A; Burg JR; Weigel WW
Food Chem Toxicol 1988 Mar; 26(3):247-254
The teratological effects of the inhalation of n-propanol (71238) and isopropanol (67630) were evaluated in rats. Pregnant female Sprague-Dawley-rats were exposed to the vapors of either isopropanol or n-propanol at concentrations of 3500, 7000, or 10,000 parts per million (ppm) in inhalation chambers for 7 hours per day on gestation days one through 19. The animals were sacrificed on gestation day 20, and the uterus, ovaries, corpora lutea, resorptions, and live fetuses were assessed. Exposure concentrations of 3500ppm and 7000ppm n-propanol and isopropanol had no significant effects on the female rats. Animals exposed to 10,000ppm isopropanol were narcotized at the end of their daily exposure whereas the same exposure concentration of n-propanol had minimal effects on the dams. The exposure of young female animals to 10,000ppm isopropanol for 7 hours resulted in narcotization followed by recovery whereas the same concentration of n-propanol resulted in narcotization followed by death. Reduced feed intake and weight gains were observed in dams exposed to 7000ppm and 10,000ppm isopropanol. Severe embryotoxicity was observed after gestational treatment with 10,000ppm n-propanol or isopropanol. Dose dependent reductions of fetal weight were observed after treatment with 7000 and 10,000ppm n-propanol and after treatment with all concentrations of isopropanol. Treatment with 10,000ppm n-propanol was associated with increased incidence of missing or short tails, ectrodactyly, rudimentary cervical ribs, and cardiovascular and urinary defects. Treatment with 7000 and 10,000ppm isopropanol was associated with rudimentary cervical ribs only. The authors conclude from the lack of effects at 3500ppm that n-propanol and isopropanol do not pose selective hazards to fetal development.
NIOSH-Author; Alcohols; Toxic-effects; Organic-vapors; Laboratory-animals; Reproductive-effects; Organic-solvents; Teratogens; Teratology
B. K. Nelson, Division of Biomedical and Behavioral Science, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, C-24, Cincinnati, OH 45226
Issue of Publication
Food and Chemical Toxicology
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division