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Walk-through survey report of oral contraceptive manufacturing at Searle and Company (Caguas), San Juan, Puerto Rico.
Zaebst D; Tanaka S; Haring M
Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, IWS 85-13, 1979 Sep; :1-16
An on site visit was made to the Searle and Company facility located in Caguas, Puerto Rico, to investigate the suitability of this facility for inclusion in a study of occupational exposure to estrogens. Approximately 90 individuals were involved in making and packaging of oral contraceptives. There were four major jobs where workers were exposed: manufacturing area workers, packaging area workers, quality assurance checkers, and maintenance and custodial personnel. Air samples were obtained at strategic locations in areas where granulation and tableting were being done. Wipe samples were also gathered from the granulating, tableting and packaging areas. No analysis was made of these samples as the filter matrices used were found not to be suitable due to interfering compounds present in the filter material. The authors conclude that this facility is not acceptable for inclusion in the larger study since there are only a few exposed workers, the exposure period is relatively short, women are excluded from the manufacturing areas, and product exposure data is limited. Medical and industrial hygiene studies might be feasible, possibly in combination with several other facilities.
NIOSH-Author; NIOSH-Survey; Field-Study; Region-2; Pharmaceutical-industry; Dust-inhalation; Dust-exposure; Airborne-dusts; Reproductive-system-disorders; Epidemiology
Field Studies; Industry Wide
NTIS Accession No.
National Institute for Occupational Safety and Health
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division