A theoretical analysis was presented of the reduction in the variability of exposure to chemicals over short periods of time because of delayed accumulation in the tissues (physiological damping). A first order autoregressive model was used to describe the time course of short term exposure. Physiological damping was measured by a transmission factor, defined as the ratio of the coefficients of variation of burden and exposure. Since some chemicals were not intrinsically toxic, but were activated to toxic species by metabolism, transmission factors were determined in terms of the burden of metabolite associated with exposure to the parent chemical. Transmission of variability of exposure to the body was decreased as the biological half times of elimination and metabolism increased and was enhanced as the autocorrelation of a series of inhaled air concentrations increased. The authors conclude that since autocorrelation is linked to the air exchange rate, the hygienist might be justified in increasing the amount of general ventilation and turbulence in the workplace rather than in focusing exclusively upon the amount of toxicant emitted.
Links with this icon indicate that you are leaving the CDC website.
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.
Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.
You will be subject to the destination website's privacy policy when you follow the link.
CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website.
For more information on CDC's web notification policies, see Website Disclaimers.
CDC.gov Privacy Settings
We take your privacy seriously. You can review and change the way we collect information below.
These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site. All information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance.
Cookies used to make website functionality more relevant to you. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests.
Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data.
Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. These cookies may also be used for advertising purposes by these third parties.
Thank you for taking the time to confirm your preferences. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page.