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Comparison of behavioral teratogenic effects of ethanol and n- propanol administered by inhalation to rats.
Nelson-BK; Brightwell-WS; Burg-JR
Neurobehav Toxicol Teratol 1985 Nov; 7(6):779-783
The effects of inhalation of ethanol (64175) and n-propanol (71238) on reproduction were investigated using male and pregnant female Sprague-Dawley-rats. The animals were exposed to 0, 10,000, or 16,000 parts per million (ppm) ethanol or 0, 35,000 or 7,000ppm n- propanol for 7 hours/day either for a 6 week period or during the period of gestation. Exposure to 10,000 or 16,000ppm ethanol had no effect on weight gain, feed and water intake or fertility. Males exposed to 7,000ppm n-propanol demonstrated reduced fertility; no other adverse effects were noted for propanol exposure in either sex. Behavioral testing among the offspring demonstrated no differences from controls following paternal or maternal exposure to these alcohols. At the higher n-propanol concentration, several of the offspring had crooked tails. A method was given for calculating the blood alcohol content based on inhalation exposure levels. These calculated blood alcohol concentrations for the animals exposed to ethanol were close to the actual measurements of blood alcohol levels. A comparison was offered between the blood alcohol levels achieved through inhalation exposures and those attained through other exposure routes.
NIOSH-Author; Organic-solvents; Teratogenesis; Reproductive-system-disorders; Neuropathology; Behavioral-testing; Blood-analysis; Reproductive-hazards; Laboratory-animals
Issue of Publication
Neurobehavioral Toxicology and Teratology
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division