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Walk-Through Survey Report of Burns-Biotec Laboratories, Omaha, Nebraska, Report No. IWS-131-17.
NIOSH 1981 Apr:26 pages
In efforts to understand risks to workers engaged in research with recombinant DNA processes and associated industries, a walk through survey was conducted at Burns-Biotec Laboratories (SIC-2834) near Omaha, Nebraska. At this facility, human leukocyte interferon production was carried out using recombinant DNA fermentation techniques in facilities separate from other work at the company. Six employees were assigned to the recombinant DNA project; 45 employees worked at the facility. An Institutional Bio-Safety Committee was formed in compliance with National Institutes of Health (NIH) guidelines. Environmental monitoring involved placement of agar filled settling plates around fermentation apparatus to monitor leakage of Escherichia-coli. Workers were required to report all injuries to health services and the Principal Investigator within 48 hours, including accidental inoculation, ingestion, or probable inhalation as well as lacerations and abrasions. Spills or escape of organisms containing recombinant DNA molecules were immediately reported to the safety officer. Engineering controls included fermenter exhaust gas filtration and waste product controls which were within NIH guidelines. Work practices and emergency and accident procedures were reviewed. The authors conclude that Burns-Biotec Laboratories are meeting various relevant safety issues in a responsible manner. Specific recommendations are offered concerning validation procedures, facility design, work practices, and a medical surveillance program.
NIOSH-Author; NIOSH-Survey; Field-Study; IWS-131-17; Region-7; Medical-research; Laboratory-workers; Safety-practices; Biohazards; Accident-prevention; Deoxyribonucleic-acid-replication;
NTIS Accession No.
Division of Surveillance, Hazard Evaluations, and Field Studies, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, Report No. IWS-131-17, 26 pages
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division