Factors Influencing Biological Responses to Chemicals.
Mechanisms of Cell Injury: Implications for Human Health 1987:315-331
Factors influencing biological responses to environmental chemical exposure were examined with emphasis on biological differences in subjects that influenced susceptibility to toxic chemicals. Factors were identified as intrinsic or extrinsic. Nutritional status significantly modified host susceptibility and was associated with increased or decreased chance that chemical exposure would result in adverse health effects; the physiological basis for nutritional effects on chemical toxicity varied with both the type of contaminant and nutrient. Many of the age related differences in chemical susceptibility were associated with altered absorption, distribution, biotransformation, and/or elimination of the chemical; gastrointestinal tract absorption, lung absorption, and tissue distribution and effect were also considered. The greater vulnerability of neonates was primarily attributed to greater absorption across membranes and the developmental pattern of detoxifying enzymes. Additional host factors influencing response to chemicals included effects of concurrent exposure to other chemicals and gender of the subject.
Risk-factors; Biological-effects; Biohazards; Environmental-exposure; Environmental-hazards; Toxic-effects; Biological-factors; Physiological-response;
Mechanisms of Cell Injury: Implications for Human Health