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Respiratory tract deposition of polydisperse aerosols in humans.
Am Ind Hyg Assoc J 1983 Jan; 44(1):62-65
The deposition of polydisperse aerosols of uniform composition using a computational model was investigated. For the purposes of this study the size distribution function adopted for the polydisperse aerosol was the lognormal distribution. This assumption was appropriate for single component aerosols. Total mass deposition fraction via nose and mouth breathing was calculated for a breathing condition of 1000 cubic centimeters tidal volume with 15 respirations per minute. Total deposition in the respiratory system approaches 100 percent for a monodisperse aerosol when particle diameter is greater than 10 micrometers or smaller than 0.005 micrometers. Deposition of polydisperse aerosols was expected to be lower than that of the monodisperse aerosol because the mass median diameter of the polydisperse aerosol was close to these values. The effect of particle size was further complicated by the sequential filtering effect of the various compartments in the respiratory system. The mobility of large particles was another problem in dealing with the deposition of polydisperse aerosols as this mobility is governed by the aerodynamic diameter while the geometric diameter is responsible for diffusion.
NIOSH-Publication; NIOSH-Grant; Aerosol-sampling; Airborne-particles; Pulmonary-system-disorders; Inhalants; Analytical-methods; Lung-burden
Issue of Publication
American Industrial Hygiene Association Journal
State University of New York at Buffalo, Buffalo, New York