Study of Lung Structure and Function with Aerosols.
Institute of Environmental Medicine, New York Medical Center, :11 pages
A discussion was presented on progress made from October 1, 1966, through December 31, 1970, on the use of aerosols in the measurement of the dimensions of air spaces in the human lung. This investigation was expected to result in the development of diagnostic procedures useful in characterizing chronic obstructive pulmonary disease, a general term including chronic bronchitis and emphysema, either singly or both together. The breathing apparatus was completely redesigned to incorporate many superior features, both in control of the breathing sequence and in aerosol measurement. The redesigned apparatus was tested in Bellevue Hospital on patients having bronchitis with emphysema, on patients having emphysema without bronchitis, and on normal subjects. During the latter half of 1970, the apparatus was set up at the Appalachian Laboratories for Occupational Respiratory Diseases, where it was undergoing further testing. From these results, it was possible to construct curves showing the effect of depth of inhalation of the aerosol bolus and time of breath holding, as well as to estimate the fraction of aerosol deposited or not deposited at 0, 10, and 20 seconds breath holding times. Theoretical considerations concerning the behavior of aerosols in small confined spaces were briefly discussed. However, there was no acceptable model for the interaction of aerosol particles with lung surfaces. The author notes that additional information is being obtained with this system on some mechanisms for pulmonary ventilation and particle behavior.
NIOSH-Grant; Pulmonary-function; Humans; Diagnostic-techniques; Pulmonary-system-disorders; Spirometry; Respiratory-gas-transport; Airway-obstruction; Physiopathology;
Environmental Medicine New York Univ Med Ctr 550 First Avenue New York, N Y 10016
NTIS Accession No.
Institute of Environmental Medicine, New York Medical Center 11 pages, 5 references
New York University, New York, New York