Toxicology and hazard assessment of 1,3-dichloropropene (Telone II).
Arch Environ Health 1987 Sep; 42(5):292-296
The toxicity of the subsoil fumigant 1,3-dichloropropene (542756) (DCP) was reviewed, and the chemical properties and environmental fate of DCP were discussed. The commercially marketed formulation of DCP known as Telone-II consists of cis and trans DCP isomers. Both isomers are hydrolyzed to their corresponding 3-chloroallyl alcohols in wet soils. Halflives for hydrolytic degradation of the isomers have been estimated to be between 3 and 25 days at 20 degrees-C. Laboratory animal studies have indicated that the liver and kidney are target organs after acute and chronic oral exposure and the lung, liver, and kidney after inhalation exposure. DCP has shown eye and mucous membrane irritating properties. DCP appears to be metabolized primarily to mercapturic acid conjugates. DCP has demonstrated mutagenic activity in several tester strains of the Ames/Salmonella assay. DCP has demonstrated carcinogenic activity in rats and mice after oral or skin exposure. Preliminary results from an inhalation study have indicated that DCP is not carcinogenic. It was unclear whether DCP poses a cancer risk to humans. DCP has been shown to be a skin irritant. The liquid and vapor can be irritating to the eyes and mucous membranes. Evidence of hepatotoxicity (elevation of serum enzymes associated with liver function) has also been observed. The human health hazards posed by DCP were summarized. Due to its odor, exposure to high concentrations likely to cause injury are not considered likely under normal conditions. The author recommends that respiratory protection be used when DCP is handled. Contact with the eyes should be avoided.
NIOSH-Author; Organo-chlorine-compounds; Unsaturated-compounds; Fumigants; Risk-analysis; Mutagenesis; Carcinogenesis; Bioassays; Pesticides; In-vivo-studies; Chemical-properties
Archives of Environmental Health