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Stimulus-Secretion Coupling in Phagocytic Cells.

Authors
Castranova-V; Scott-MR; Dyke-K
Source
Cellular Chemiluminescence. Van Dyke K, Castranova V, eds. Boca Raton, FL: CRC Press, 1987 Jan; 1:131-160
Link
NIOSHTIC No.
00175642
Abstract
A review of stimulus secretion coupling in phagocytic cells, based on a general scheme for stimulus secretion systems, was presented. An overview of stimulus secretion coupling in other cell systems was presented and a general scheme was proposed. One problem in studying stimulus response coupling in phagocytic cells is the fact that data are derived from four different cell types: peripheral granulocytes, peritoneal neutrophils, peripheral monocytes, and alveolar macrophages. Binding of stimulants to membrane receptors and characteristics of these receptors were described. Stimulant induced changes in transmembrane potential measured by four techniques were considered. Strong, although not conclusive, evidence was presented for the role of depolarization of phagocyte membranes in stimulus secretion coupling. Stimulant induced changes in membrane transport properties were addressed. Mobilization of intracellular calcium as a factor for secretory activity of phagocytes was discussed. The role of calmodulin in the stimulation response scheme of phagocytes was considered. Involvement of cyclic- adenosine-monophosphate in the stimulus secretion cycle was addressed. Stimulant induced protein phosphorylation was considered. Stimulation of lipid metabolism and its role in phagocytosis were described. Stimulant induced changes in cytoskeletal components were discussed. A working hypothesis for the stimulus response coupling cascade of phagocytic cells was illustrated.
Keywords
In-vitro-studies; Cellular-reactions; Blood-cells; Cell-metabolism; Adenosines; Phagocytes; Humans; Laboratory-animals; Plasma-membrane; Metabolic-study;
Publication Date
19870101
Editors
Van Dyke-K; Castranova-V
Fiscal Year
1987
ISBN No.
9780849343322
Source Name
Cellular Chemiluminescence
State
FL;
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division