The uses of epidemiology in the study of neurotoxic pollutants: lessons from the workplace.
Int J Ment Health 1985 Jan; 14(3):44-63
Examples were presented in this review of neurologic and psychiatric syndromes which have evolved through exposure to hazardous chemicals in the workplace. Clinical recognition of the problem has been the first step in demonstrating a toxic etiology for an existing condition. An exposure history must be gathered including occupational, environmental, and drug ingestion histories. Three case histories were presented where history gathering revealed a common link. The first involved bladder dysfunction in workers at a factory producing polyurethane plastic armrests for automobiles. The second concerned neuropsychiatric illness in workers exposed to chlordecone (143500) at a chemical facility in Hopewell, Virginia. The third involved a neurological impairment in three patients who worked at a plastics factory. Epidemiologic follow up in the first case implicated exposure to the catalyst dimethylaminopropionitrile (1738256) as the cause of the bladder dysfunction. Extremely bad working conditions with high exposures to chlordecone were found at the Hopewell facility. In the third case, exposure to 2-t-butylazo- 2-hydroxy-5-methylhexane (BHMH) was determined to be the causative agent. In each of these three cases, a degree of toxicologic corroboration was achieved in laboratory animal studies.
NIOSH-Author; Epidemiology; Neuropathology; Neurotoxic-effects; Psychomotor-disorders; Peripheral-nervous-system; Central-nervous-system; Neurological-reactions; Laboratory-animals
Neurotoxic Disorders; Neurotoxic-effects
International Journal of Mental Health