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Neurobehavioral testing of chemicals: impact on recommended standards.
Neurobehav Toxicol Teratol 1984 Jan; 6(2):147-153
Chemicals for which neurotoxicity produced by acute or chronic exposures has served as a basis for changes in recommended workplace standards were identified, and future research in behavioral toxicology which can contribute to recommended standards was suggested. Threshold limit values (TLVs), the limit of an airborne substance to which workers can likely be exposed without experiencing ill effects, were proposed for 588 chemicals by the American Conference of Governmental Industrial Hygienists (ACGIH) in 1982 with several bases for making these recommendations. Some of the bases were that the chemical was an irritant to various body tissues, that it affected specific target organs leading to disease states or weakening of those organs, that it affected certain body systems such as the respiratory or gastrointestinal systems, or that the chemical possessed teratogenic or mutagenic properties. Several of these chemicals affected the nervous system. Neurotoxic effects were subdivided into several categories: motor, sensory, cognitive, general changes, and affective/personality. A listing of 167 chemicals for which the ACGIH cited neurotoxic effects as a basis for establishing the limit of airborne concentrations of these chemicals which may be permitted in a workplace was provided.
NIOSH-Author; Nervous-system-disorders; Neurological-diseases; Health-standards; Neurological-system; Neuromotor-system; Industrial-safety; Neuromuscular-system-disorders; Neuropathology; Industrial-hazards; Worker-health
Issue of Publication
Neurobehavioral Toxicology and Teratology
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division