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Airway epithelium modulates the reactivity of guinea-pig respiratory smooth muscle.

Authors
Hay-DW; Farmer-SG; Raeburn-D; Robinson-VA; Fleming-WW; Fedan-JS
Source
Eur J Pharmacol 1986 Sep; 129(1-2):11-18
NIOSHTIC No.
00174931
Abstract
The reactivity of guinea-pig isolated trachea was studied with and without removal of airway epithelium. Dose response contractile curves were obtained for potassium-chloride (KCl), histamine, and methacholine in the presence and absence of indomethacin. Epithelium removal had no significant effect on the mechanical properties of isolated tracheal strips but increased the sensitivity of the tissue to both histamine and methacholine. The maximum contractile response of the tissue after epithelium removal was increased for histamine but was unchanged for methacholine. Epithelium removal yielded variable results for maximum contractile response to KCl treatment. Indomethacin incubation induced tissue relaxation in intact and epithelium denuded tracheal strips. Indomethacin treatment enhanced the maximal contractile response to KCl in the absence of epithelium and increased tissue sensitivity to methacholine in intact preparations. Indomethacin had no effect on tissue responses to histamine. The authors conclude that inhibitory and excitatory factors from epithelial cells regulate the reactivity of guinea-pig isolated airway smooth muscle.
Keywords
NIOSH-Author; Laboratory-animals; Lung-tissue; In-vitro-studies; Physiological-response; Neuromuscular-function; Pulmonary-function; Muscle-cells; Dose-response
CODEN
EJPHAZ
Publication Date
19860923
Document Type
Journal Article
Fiscal Year
1986
Issue of Publication
1-2
ISSN
0014-2999
Source Name
European Journal of Pharmacology
Page last reviewed: April 12, 2019
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