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Arsenic - state of the art.
Am J Ind Med 1981; 2(1):5-14
Arsenic (7440382) exposure was reviewed with regard to occupational burden, toxicity, and studies of arsenic carcinogenicity and mutagenicity. The principal source of occupational exposure has been the removal of arsenic from copper, lead, and zinc ores during smelting operations. Estimates from NIOSH have indicated that 1.5 million workers in the United States are potentially exposed to arsenic on the job. These figures include approximately 660,000 persons with direct exposure potential. Human absorption of arsenic is determined primarily by the measurement of total arsenic concentrations in hair and urine. Urine arsenic levels have been used as indicators of recent exposure whereas hair arsenic levels indicate past arsenic exposure. The toxicity of trivalent arsenic has been shown to be greater than that of pentavalent arsenic. Subacute and chronic toxicities were discussed with regard to dermal, neural, hepatic, cardiovascular, respiratory, and hematopoietic effects. Mutagenic effects attributable to arsenic dosing have been demonstrated in Syrian-hamster cells. Epidemiological studies have indicated a relationship between arsenic exposure and cancers of the skin, liver, and lung and possibly those of lymphatic and hematopoietic tissues, although no animal model for arsenic related cancer induction has been found.
NIOSH-Author; Carcinogenesis; Mutagens; Arsenic-compounds; Occupational-exposure; Body-burden; Urinalysis; Worker-health; Heavy-metals; Hepatotoxicity; Exposure-levels; Toxic-effects; Smelters; Pesticides-and-agricultural-chemicals; Author Keywords: arsenic; mutagenesis; lung cancer; angiosarcoma of liver; skin cancer; neuropathy
Philip Landrigan, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, 4676 Columbia Parkway, Cincinnati, OH 45226
Issue of Publication
American Journal of Industrial Medicine
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division