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Ethylene glycol monomethyl ether (EGME) inhibits rat embryo ornithine decarboxylase (ODC) activity.
Toraason M; Breitenstein MJ; Smith RJ
Drug Chem Toxicol 1986; 9(3/4):191-203
The effect of the anti-icing additive, ethylene-glycol-monomethyl- ether (109864) (EGME), on embryo ornithine-decarboxylase (ODC) activity during organogenesis was assessed in rats. Pregnant Sprague-Dawley-rats were treated with 0, 25, 50, or 75mg/kg EGME by gavage on gestation days 6 through 12. The animals were sacrificed on gestation days 9, 11, 13, 15, or 25 if they had not yet delivered, and ODC assays were performed on the embryos. EGME treatment had no effect on maternal weight gain during gestation, but did affect the reproductive outcome in a dose dependent manner. Dose levels of 50 and 75mg/kg EGME reduced delivery of litters by 50 and 100 percent, respectively. EGME treatment also reduced pup weight, decreased litter size, and significantly prolonged gestation. Embryonic ODC activity peaked on gestation day 11, and dose dependent effects of EGME treatment on ODC activity were only observed at that time. The administration of 75mg/kg EGME to dams on gestation day 11 decreased embryonic ODC activity by 60 percent. The authors conclude that EGME treatment in rats causes developmental toxicity in the absence of maternal toxicity. They note that the highest dose resulted in dams carrying litters to term but not delivering, and they suggest that the EGME effect may be to interfere in some way with parturition.
NIOSH-Author; Laboratory-animals; Organic-solvents; Teratogens; Ethylenic-alcohols; Toxic-effects; Enzyme-activity; Reproductive-effects; Enzymatic-effects; In-vivo-studies; Embryotoxicity; Dose-response
Mark Toraason, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Biomedical and Behavioral Science, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, Ohio 45226
Issue of Publication
Drug and Chemical Toxicology
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division