Action of antischistosomal drugs, hycanthone and its analog IA-4 N- Oxide, on viral interferon induction.
J Toxicol Environ Health 1980 Jan; 6:705-712
Studies were conducted to determine the response of mammalian cell cultures treated with two antischistosomal drugs, hycanthone (3105973) and its indazole analog IA-4-N-oxide, on the induction of interferon by influenza virus and on interferon mediated antiviral cellular resistance. Rhesus-monkey kidney cells and Chang human conjunctiva cells were used for the induction and assay of interferon, respectively. Hycanthone was more cytocidal than the analog. Increased concentrations of hycanthone, ranging from 0.1 to 10 micrograms per milliliter, progressively reduced viral interferon yields as much as 73 percent compared to that of controls. Comparable concentrations of the analog had no adverse effect on interferon production. Pretreatment of cell cultures with the analog nullified the adverse effect of hycanthone on viral interferon induction; the analog, however, could not limit the inhibitory effect of pretreatment with hycanthone. Interferon mediated antiviral cellular resistance was not affected when cell cultures were pretreated with hycanthone or the analog. The authors suggest that there is a possible relationship between mutagenicity of antischistosomal drugs and their ability to depress interferon synthesis.
NIOSH-Author; Mutagens; Mutagenesis; Infectious-diseases; Therapeutic-agents; Drug-therapy; Pharmaceuticals; Cytology; Cytochemistry
Journal of Toxicology and Environmental Health