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IgA glomerulonephritis in a plumber working with solvent-based pipe cement.
Albrecht WN; Boiano JM; Smith RD
Ind Health 1987 Jul; 25(3):157-158
A case was described of a 28 year old plumber who suffered from gross hematuria and segmental proliferative glomerulonephritis with immunoglobulin-A deposits who requested a health hazard evaluation from NIOSH. A detailed examination of needle biopsy material revealed the presence of capillary adhesions to Bowman's capsule and fibrin in the glomerular mesangial deposits, which was suggestive of a progressive autoimmune disease. He had been working with plastic pipe and plastic cement for 9.5 years and had no family history of kidney disease. Monitoring of his workplace identified a very high exposure (range, 389 to 757 parts per million (ppm)) to tetrahydrofuran (109999) (THF), which is a component of polyvinyl- chloride pipe cement. The high exposure values occurred while the plumber glued pipe sections in confined spaces. He was also potentially exposed to cyclohexanone (108941) and methylethyl-ketone (78933) which were also present in the cement. The concentration of cyclohexanone was not measurable, but that of methylethyl-ketone was in the range of 3.9 to 5.0ppm. The short term exposure limit for THF recommended by NIOSH is 250ppm. Although the authors do not conclude that the immunoglobulin-A nephropathy has been caused by THF, they suggest that a predisposition toward the disease could be exacerbated by the massive short term exposure to solvent.
NIOSH-Author; Plumbers; Nephrological-disorders; Kidney-lesions; Occupational-exposure; Furans; Vinyl-plastics; Case-studies; Organic-solvents; Author Keywords: IgA glomerulonephritis; Tetrahydrofuran; THF; Solvents; Occupational kidney disease; Plumbing hazards
William N. Albrecht, National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, Cincinnati, Ohio 45226, U.S.A.
109-99-9; 108-94-1; 78-93-3
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Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division