Comparison of neoplastic hepatic lesions in man and experimental animals.
Popper H; Selikoff IJ; Maltoni C; Squire RA; Thomas LB
Origins of human cancer. Book C. Human risk assessment. Hiatt HH, Watson JD, Winsten JA, eds. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1977 Jan; 4:1359-1382
The development of hepatic nodular proliferations in laboratory animals and in humans exposed to steroids was reviewed. Topics included: nodular lesions in rodents, including neoplastic nodules, hepatocellular adenoma, and nodular variations; steroid hepatocellular tumors in women of childbearing age who had taken contraceptive steroids and in men and women who had taken anabolic steroids; pathogenesis and clinical implications of steroid nodular lesions; vinyl-chloride (75014) induced lesions in man and rodents; and pathogenesis and clinical implications of antecedent lesions and angiosarcoma associated with exposure to chemicals. The authors conclude that the similarity in the development of the lesions in rodents and humans may support the predictive nature of animal experimental studies for carcinogenesis in man. The major differences between experimental studies in rodents and tumors found in humans was the greater fibroplastic reaction in humans. The concept of multiple cell populations in hepatocarcinogenesis was supported by the development of hepatocellular carcinomas within nodules in both rodents and humans.
NIOSH-Grant; Laboratory-animals; Liver-cancer; Pathomorphology; In-vivo-studies; Hepatotoxicity; Liver-tumors
Hiatt HH; Watson JD; Winsten JA
Origins of human cancer. Book C. Human risk assessment