The Influence of Theoretical and Experimental Radiobiology on the Epidemiology of Radiation Carcinogenesis.
NIOSH 1985 May:24 pages
The contribution of a number of factors to the risk of developing cancer after exposure to ionizing radiation were discussed. These factors included the radiation dose and its distribution in time and space; the time period following exposure; the sex, age, and genetic background of the irradiated individual; and other exposures or life events before or after irradiation. According to the author, the radiation dose can be determined with great precision; it is therefore possible that existing data may contain more information than has been collected so far. The discussion of dose response relationship involved a detailed explanation of the mechanism by which ionizing radiation affects specific loci in a cell. It was hypothesized that cancer is more likely to result from ionizing events that have occurred within a short time than from those that are more widely separated, and it is pointed out that this hypothesis can be tested in experimental models. DNA repair may neutralize a radiation effect before a new exposure occurs, but mammary cancer seems to be an exception to this. Sensitivity to radiation carcinogenesis generally varies according to age at exposure but other risk factors such as cigarette smoking must also be considered. The author concludes that the continuous development of theoretical models provides more and more interesting questions to be answered.
Epidemiology; Risk-analysis; Biostatistics; Humans; Cancer-rates; Radon-daughters; Radiation-hazards; Ionizing-radiation;
Proceedings of a Symposium on Epidemiology and Health Risk Assessment, Columbia, Maryland, May 14-16, 1985, Centers for Disease Control/NIOSH, 24 pages, 33 references