Leukemia risks in relation to benzene exposures: an examination of the data.
NIOSH 1985 May; :1-13
The relationship between the development of leukemia and exposure to benzene (71432) was discussed. Most of the studies reviewed were published between 1974 and 1983, and six of the reports were discussed in some detail. Incidences of benzene induced leukemia have been reported in shoe workers, pliofilm workers, and refinery workers. The benzene concentrations varied between 0.1 and several hundred parts per million and the duration of the exposure was several years (8 hours per day). However, there was some question as to the actual exposure levels for individuals. In one study, the relative risk of leukemia was estimated to be 1.1 to 2.0 compared to a nonexposed population, while other studies reported relative risks of 4.74, 2.17, and zero. It is pointed out that differences in data quality, manner of reporting, and other variables make a direct comparison between the studies difficult. It is also suggested that the term "environmental data" should be used instead of "exposure data" since the individual exposures can only be inferred. The author concludes that the studies should be independently confirmed elsewhere, and that the conditions of exposure should be more carefully demonstrated.
Epidemiology; Leukemogenesis; Risk-analysis; Biostatistics; Humans; Cancer-rates; Carcinogenicity; Monocyclic-aromatic-hydrocarbons
Proceedings of a Symposium on Epidemiology and Health Risk Assessment, Columbia, Maryland, May 14-16, 1985, Centers for Disease Control/NIOSH, 13 pages, 15 references