The 28 contributions to this symposium dealt with various aspects of epidemiology as it relates to the assessment of various risks to the health of workers arising out of hazardous materials or conditions at the workplace. The symposium began with an overview of health risk assessment considering epidemiology and environmental hazards, the scientific basis for policy decisions, epidemiology and risk assessment, and toxicology and epidemiology. Contributions of epidemiology to health risk assessment were considered including estimation of risk and inferring causality in epidemiology, developmental risks, asbestos (1332214) and cancer, genetic susceptibility and the estimation of risk. When considering various refinements to epidemiological approaches to the assessment of exposure both measurements taken in the total environment and measurements in the individual were discussed. The quantitative expression of risk was considered including quantitative expression of dose responses, statistical modeling of dose response relationships, and quantification of risk in defined populations. In the papers evaluating epidemiologic information, methods for combining animal and human data were considered along with papers on saccharin and bladder cancer, estrogens and breast cancer, leukemia risks in relation to benzene (71432) exposure, the influence of theoretical and experimental radiobiology on the epidemiology of radiation carcinogenesis, soft water and hardening of the arteries, and the circumstances of exposure and reproductive consequences.
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