A study of the ability of chemical protective clothing materials to resist chemical penetration was conducted. The glove materials nitrile, neoprene, polyvinylchloride, natural latex, and natural rubber were tested against aniline (62533), cyclohexylamine (108918), diisopropylamine (108189) (DIPA), tertiary-butylamine (75649) (TBA), morpholine (110918), and carbon-disulfide (75150) using the NIOSH Chemical Protective Clothing Portable Test Method at a chemical facility. A smaller, less expensive permeation cell and three types of portable organic vapor detectors, a hydrocarbon detector, a photoionization detector, and a portable gas chromatograph with a flame ionization detector, were used to detect the agents penetrating into the collection side of the cell. Chemical breakthrough times were measured. Aniline had too low a vapor pressure for the detectors to measure it reliably. For the other materials, breakthrough times ranged from 1 minute for the polyvinylchloride glove material against TBA to more than 3 hours for the nitrile material against DIPA. The authors conclude that the method can be used to rapidly evaluate candidate materials for protective clothing.