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Relative potency of four ethylene glycol ethers for induction of paw malformations in the CD-1 mouse.
Teratology 1987 Jun; 35(3):321-328
The pattern of paw malformations induced in CD-1-mouse fetuses by single maternal doses of dimethyl substituted ethylene glycol ethers was compared to that produced by ethylene-glycol-monomethyl-ether (109864) (EGME). Fetal paw malformations were quantitated following single equimolar doses of EGME, ethylene-glycol-dimethyl-ether (110714) (EGDME), diethylene-glycol-dimethyl-ether (111966) (DEGDME), and triethylene-glycol-dimethyl-ether (112492) (TEGDME) administered on day 11 of pregnancy. Fetuses were collected on day 18 of pregnancy and examined for paw malformations. These compounds were not toxic to the maternal rats at the concentrations utilized and did not affect uterine survival significantly. While only EGDME caused significant reductions in fetal weight, each compound except TEGDME produced a significant number of fetal paw malformations. Such malformations occurred in 87.5 percent, 86.7 percent, and 77.8 percent of litters from rats treated with EGME, EGDME, and DEGDME, respectively. Syndactyly was the most frequently encountered malformation observed, occurring more frequently in hindpaws than in forepaws. Other malformations encountered included oligodactyly and reduced digit size. The authors conclude that each of the active compounds is metabolized to a common teratogen, methoxyacetic-acid (625456).
NIOSH-Author; Embryotoxicity; Toxic-effects; In-vivo-studies; Teratology; Glycols; Metabolites; Laboratory-animals; Ethers; Comparative-toxicology; Transplacental-exposure; Developmental-disorders
109-86-4; 110-71-4; 111-96-6; 112-49-2; 625-45-6
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Page last reviewed: March 11, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division