Chronic Inhalation Toxicity of 1,2-Dibromoethane in Rats. With and Without Dietary Disulfiram.
Wong-LC; Winston-JM; Hong-CB; Hagensen-J
NIOSH 1980 Nov:36 pages
The effects of chronic exposure to 20 parts per million (ppm) 1,2- dibromoethane (106934) (EDB) were studied in Sprague-Dawley-rats. Male and female rats were exposed to EDB for 7 hours/day, 5 days/week for 18 months; some rats were also given a diet containing disulfiram resulted in most of the rats dying or being terminated during the first 12 months; all rats in this group died or were terminated by the fifteenth month. The group receiving EDB alone had higher mortality than a control group or a group receiving disulfiram alone. Body weight was depressed in the EDB/disulfiram group to a greater extent than in the EDB group. The EDB/disulfiram group showed a significant increase in the incidence of tumors of the liver and mesentery, compared to the group receiving EDB alone. EDB/disulfiram resulted in a tenfold increase in hepatocellular carcinoma, compared to EDB alone. Testicular atrophy was found in 88 percent of the EDB/disulfiram males, but in only 2 percent of EDB males. Histopathologic changes were observed in nasal cavities of rats treated with EDB or EDB/disulfiram. The authors conclude that inhalation of EDB at 20ppm under simulated occupational conditions exerts a carcinogenic effect; addition of disulfiram to the diet enhances the toxicity and carcinogenicity of EDB, and results in additional effects.
NIOSH-Contract; Contract-210-76-0131; Brominated-ethanes; Laboratory-animals; Chronic-exposure; Carcinogens; Reproductive-system-disorders; Sex-factors;
NTIS Accession No.
Fertility and Pregnancy Abnormalities; Disease and Injury; Reproductive-system-disorders; Special Populations; Work Environment and Workforce;
Division of Biomedical and Behavioral Science, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio