Spermatotoxicity associated with acute and cubchronic ethoxyethanol treatment.
Zenick-H; Oudiz-D; Niewenhuis-RJ
Environ Health Perspect 1984 Aug; 57:225-231
A study was conducted in rats (male and female Long-Evans-hooded- rats) on the effects of ethoxyethanol (110805) (EE) on sperm counts, shape, and motility. Initially, the baseline ejaculates in female genital tracts were evaluated. Two days after baseline evaluation, intubation for 5 consecutive days, and at the end of this period the animals were mated. Four, 7, 10, and 14 weeks after cessation of the treatment, the sperm obtained from ejaculates was evaluated. All animals were sacrificed at week 16. Although EE treatment did not change the copulatory behavior of the rats, it caused a significant decline in the sperm counts in all groups. By 7 weeks, animals in the two highest dose groups were unable to produce sperm, but some degree of recovery was evident 10 weeks after EE exposure. The proportion of abnormally shaped sperm increased significantly at 7 weeks after exposure. Some testicular lesions were noted histologically, and pachytene spermatocytes were seen to be the most sensitive germ cell population. In a modification of the study, animals were treated 5 days a week for 6 weeks, and their sperm samples were evaluated weekly. Except for the appearance of signs of systemic toxicity, the results were similar to those of the first study. The authors conclude that this study demonstrates the significant toxic effect of EE on the testes and the potential for recovery from this toxic insult.
NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Fertility; Reproductive-effects; Spermatogenesis; Spermatozoa; Glycols; Ethers; Cytopathology; Toxic-effects
Environmental Health University of Cincinnati 3223 Eden Avenue Cincinnati, Ohio 45267
Environmental Health Perspectives
University of Cincinnati, Cincinnati, Ohio