Current intelligence bulletin 17 - 2-nitropropane.
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-127, (CIB 17), 1977 Apr; :1-6
Health hazards associated with 2-nitropropane (79469), a widely used solvent in industrial coatings and printing inks, were discussed. An inhalation study conducted in male Sprague-Dawley-rats and New- Zealand-white-rabbits showed that all rats exposed to 207 parts per million (ppm) 2-nitropropane over a 6 month period developed hepatocellular carcinomas or hepatic adenomas. Tumors were not seen in animals exposed to lower levels or for shorter times, although other liver changes were seen after 1 or 3 months exposure at the high level. Additionally, liver sections from two rats exposed to 300ppm 2-nitropropane in another study, when examined by a NIOSH pathologist, showed clear cell foci similar to those frequently seen prior to the development of hepatocellular carcinomas in rats exposed to known hepatic carcinogens. Reports concerning health effects have shown that exposure to 2-nitropropane alone or in combination with 1-nitropropane (108032) causes nausea, dizziness, headache, and diarrhea. Occupational exposure to 2-nitropropane was implicated in certain cases of liver injury. Industrial hygiene practices to reduce exposure to 2-nitropropane are presented. It is noted that NIOSH plans to conduct industrial hygiene and epidemiologic studies at facilities where 2-nitropropane is manufactured or used. The author concludes that 2-nitropropane should be handled in the workplace as if it were a human carcinogen.
NIOSH-Author; NIOSH-Current-Intelligence-Bulletin-No-17; Nitro-compounds; Alkanes; Health-hazards; Protective-measures; Risk-analysis; In-vivo-studies; Laboratory-animals; Carcinogenesis; Liver-cancer; Toxic-effects; Occupational-exposure
Numbered Publication; Current Intelligence Bulletin
NTIS Accession No.
DHEW (NIOSH) Publication No. 78-127; CIB 17
National Institute for Occupational Safety and Health