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Current intelligence bulletin 12 - diethylcarbamoyl chloride (DECC).
Rockville, MD: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 78-127, (CIB 12), 1976 Jul; :1
This Current Intelligence Bulletin (CIB) briefly presents information on the genotoxic hazards associated with diethylcarbamoyl-chloride (88108) (DECC). A study of the mutagenic potential of DECC found that it was mutagenic in two strains of Escherichia-coli, (WP-2) and (WP-2S). DECC, however, was not as potent a mutagen as the closely related analog dimethylcarbamoyl- chloride (79447) (DMCC). DMCC was found to have carcinogenic activity in laboratory animals after subcutaneous, intraperitoneal, and inhalation exposure, as noted in another NIOSH CIB. Annual production of DECC in recent years amounted to less than 15000 pounds. The only known commercial use of DECC in the United States was as an intermediate in the synthesis of diethylcarbamazine- citrate, a pharmaceutical used as an anthelmintic (worming agent). Diethylcarbamazine-citrate is said to be produced and marketed as Hetrazan and Caricide by Lederle Laboratories, a division of the American Cyanamide Company.
NIOSH-Current-Intelligence-Bulletin-No-12; Organic-compounds; Mutagenesis; Bioassays; Microbial-test-systems; Risk-analysis; Health-hazards; Genetics; Chemical-synthesis
Numbered Publication; Current Intelligence Bulletin
DHEW (NIOSH) Publication No. 78-127-12; CIB 12
National Institute for Occupational Safety and Health
Page last reviewed: April 12, 2019
Content source: National Institute for Occupational Safety and Health Education and Information Division