Comparative Inhalation Teratogenicity of Three Glycol Ether Solvents in Rats.
Nelson BK; Setzer JV; Brightwell WS; Mathinos PR; Kuczuk MH; Weaver TE
Virgin female and male Sprague-Dawley-rats were mated and the pregnant females exposed to glycol ether solvents for 7 hours per day during gestation days seven through 15. A small number of animals was exposed on days 14 through 20. At concentrations of 100 parts per million (ppm), methoxyethanol (109864) (ME) caused about half of the litters to be entirely resorbed. A three fold increase in resorptions and a 20 percent reduction in fetal weights were noted at 50ppm exposure levels. The predominant malformations in both the 100 and 50ppm groups were of the heart with some malformations of the retina, eye, umbilicus, lungs, ribs and vertebrae. Butoxyethanol (111762) exposures at 250, 350, or 450 to 500ppm levels caused many fatalities and therefore the study was conducted at the 150 to 200ppm exposure level. Some hematuria was noted at the 200ppm level but no other adverse effects were noted either in the pregnant rats or the fetuses. 2-Ethoxyethyl-acetate (111159) (EEAC) caused visceral malformations of the heart and umbilicus in fetuses from the 390ppm exposure group. Three fetuses from the 390ppm group demonstrated malformations of the ribs; no skeletal malformations were noted in the 130ppm group. Exposure to higher dose levels of ME and EEAC on days 14 through 20 of gestation delayed parturition by 36 to 48 hours.
NIOSH-Author; Solvents; Ethanols; Glycols; Ethers; Reproductive-effects; Transplacental-exposure; Toxic-effects; Teratogens; Laboratory-animals;
109-86-4; 111-76-2; 111-15-9;
Division of Biomedical and Behavioral Science, NIOSH, Cincinnati, Ohio 45226, 30 pages, 24 references