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Teratogenicity of 2-ethoxyethanol by dermal application.
Hardin BD; Niemeier RW; Smith RJ; Kuczuk MH; Mathinos PR; Weaver TF
Drug Chem Toxicol 1982; 5(3):277-294
The teratogenic potential of 2-ethoxyethanol (110805) (2EE) when absorbed through skin was investigated using pregnant Sprague-Dawley- rats. On days seven through 16 of gestation, water or undiluted 2EE was applied to shaved interscapular regions of the rats, four times each day. No signs of maternal toxicity were noted with the exception of ataxia which developed in the 0.50 milliliter (ml) dose group in the last few days of treatment. Significant differences in maternal weight gain were noted for the period from day seven to 16 and from day 16 to 21. The decreased maternal weight was felt, however, to result from complete resorptions rather than from toxicity to the pregnant animal. No live fetuses were detected in the 0.50ml dose group and in the 0.25ml dose group there were significant reductions in both the mean weights of fetuses and in the number of live implants per litter. Only two fetuses demonstrated visible malformations; one had an umbilical hernia, another had no tail. Cardiovascular malformations and various types of deviations from normal skeletal development were noted. The authors caution that great care should be taken in limiting human exposure to 2EE and that skin exposure as well as previously demonstrated inhalation exposure be regarded as potentially hazardous.
NIOSH-Author; Solvents; Teratogenesis; Laboratory-animals; Transplacental-exposure; Skeletal-defects; Cardiovascular-system-disorders; Embryotoxicity
Issue of Publication
Drug and Chemical Toxicology
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division