The assessment of the dose-response relationship for low-level exposure to neurotoxicants in man.
Bleecker ML; Agnew J
Occupational and Environmental Chemical Hazards. Cellular and Biochemical Indices for Monitoring Toxicity. Foa V, Emmett EA, Maroni M, Colombi A, eds., New York: Halsted Press, 1987 Jan; :508-515
The visual reaction time recorded in 30 male workers with occupational exposure of 1 year or less to lead (7439921) (Pb) was compared to that of 60 age, sex and education matched comparisons, aged 18 to 60 years. In the exposed population, the levels of Pb in the blood ranged from 42 to 152 micrograms per deciliter, as compared to a maximum of 21 micrograms per deciliter in comparisons; the respective figures for erythrocyte protoporphyrins were 44 to 310 and 36 micrograms per deciliter. The Pb workers presented consistently longer reaction times than the comparisons. There was no correlation between reaction time and the levels of Pb in the blood, erythrocyte protoporphyrin levels, length of exposure to Pb, or combinations of these parameters. A positive correlation was identified between age and all other parameters except initial and maximum levels of Pb in the blood, but none of the correlations was statistically significant. The authors conclude that the results obtained are not compatible with an association between visual reaction time and the indicators of exposure in the group of Pb exposed workers, and that the small size of the population tested could have affected the lack of statistical associations.
NIOSH-Grant; Neurotoxicity; Biochemical-indicators; Biological-monitoring; Metallic-poisoning; Heavy-metals; Lead-compounds; Neurological-reactions; Visual-motor-performance; Humans; Occupational-exposure
Environmental Health Sciences John Hopkins University 615 N Wolfe Street Baltimore, MD 21205
Foa V; Emmett EA; Maroni M; Colombi A
Occupational and Environmental Chemical Hazards. Cellular and Biochemical Indices for Monitoring Toxicity
Johns Hopkins University, Baltimore, Maryland