NIOSH 1986 Sep; :669-670
The clinical presentation of primary lung cancer related to occupational exposures is described. Diagnosis of lung cancer is usually based upon abnormalities seen on the chest radiograph with cytology and tissue diagnosis used for confirmation. Diagnostic evaluation involves establishing the diagnosis, determining the tumor's resectability, and, if resectable, determining its operability. The importance of individualizing the diagnostic evaluation is stressed. The primary mode of treatment for nonsmall cell bronchogenic carcinoma is surgical resection with radiotherapy used for palliation. Small cell carcinoma is the bronchogenic cancer most sensitive to chemotherapy and radiation, but remission is most often short lived. The prognosis for bronchogenic carcinoma is poor with overall five year survival rates being less than 10 percent. Survival rates are better for squamous cell carcinoma and worse for small cell carcinoma. Asymptomatic patients who undergo surgical resection for a small peripheral carcinoma have shown five year survival rates of approximately 50 percent. The authors note that survival rates have changed little over the past thirty years.
NIOSH-Author; Carcinogenesis; Histopathology; Pulmonary-system-disorders; Radiation-therapy; Therapeutic-agents; Clinical-diagnosis
Book or book chapter
Foa-V; Emmett-EA; Maroni-M; Colombi-A
Occupational Respiratory Diseases. J. A. Merchant, Editor; Division of Respiratory Disease Studies, Appalachian Laboratory for Occupational Safety and Health, NIOSH, U.S. Department of Health and Human Services, DHHS (NIOSH) Publication No. 86-102