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Occupationally induced lung cancer epidemiology.

Lemen RA
Occupational respiratory diseases. Merchant JA, Bochlecke BA, Taylor G, eds. Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 86-102, 1986 Sep; :629-656
The epidemiology of occupationally induced lung cancer related to asbestos (1332214), bischloromethylether (542881) (BCME), arsenic (7440382) (As), coke oven emissions, aluminum (7429905) (Al), chromium (7440473) (Cr), nickel (7440020) (Ni), beryllium (7440417) (Be), mustard gas, fluorspar (7789755), and uranium bearing ores is reviewed. Mortality studies of defined populations of asbestos manufacturing, insulating, and shipyard workers demonstrated an association between bronchial cancer and asbestos exposure, and increased risks of lung cancer have been reported for men employed in chrysotile mines (SIC-1499) and mills in Quebec and anthophyllite mines in Finland. Smoking cigarettes has been shown to enhance the risk of lung carcinoma. Etiological links between As, Ni, and Be and lung cancer have been provided by animal research and epidemiological studies. The results of sputum cytology and lung cancer incidence studies indicated that male workers involved in the production and maintenance of anion exchange resins had an unusually high cancer risk due to BCME exposure relative to age and cigarette matched uranium surface worker controls. Unusually high lung cancer rates have also been noted for fluorspar miners, miners of uranium bearing ores, coke oven workers and workers in Al reduction facilities as well as for workers exposed to Cr in the pigment industry, plating industry, and ferrochromium industry. Respiratory tract cancer has been observed in workers manufacturing mustard gas, and mustard gas has been suggested as the agent responsible for increased lung cancer deaths among exposed soldiers during World War I.
NIOSH-Author; Carcinogenesis; Pulmonary-system-disorders; Occupational-exposure; Dust-exposure; Environmental-exposure; Mineral-dusts; Metals
1332-21-4; 542-88-1; 7440-38-2; 7429-90-5; 7440-47-3; 7440-02-0; 7440-41-7; 7789-75-5
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Document Type
Merchant JA; Bochlecke BA; Taylor G
Fiscal Year
NIOSH Division
SIC Code
Source Name
Occupational respiratory diseases
Page last reviewed: February 11, 2022
Content source: National Institute for Occupational Safety and Health Education and Information Division