Development and use of a sampling and analytical method for azodicarbonamide.
Ahrenholz SH; Neumeister CE
Am Ind Hyg Assoc J 1987 May; 48(5):442-446
A sampling and analytical method is presented for azodicarbonamide (123773) (ADCA) which was developed as part of a response to a concern about possible azodicarbonamide exposure. The method was used in two health hazard evaluations, one at an injection molding facility that used a procedure where ADCA was combined at the workplace with plastic pellets and subsequently dumped into feed hoppers on injection mold machines, and the other at a facility using powdered ADCA to make plastisols used in vinyl floor production. Teflon filters were used to collect environmental samples for total dust and airborne concentration of ADCA. Dimethyl- sulfoxide extracted samples were analyzed by high performance liquid chromatography and ultraviolet detection. Of the 221 filter samples analyzed for ADCA, 71 were blanks, none of which showed any detectable quantity of ADCA. The amount of ADCA quantitated on sampled filters ranged from less than 1 to 1168 micrograms/filter. ADCA concentrations for breathing zone samples collected in the injection molding facility ranged from below 1 to 750 micrograms/cubic meter (microg/m3). Questionnaires showed a strong association between eye, nose and throat irritation along with cough and wheezing and working in the injection molding area in which ADCA was used. At the floor covering facility, documented personal exposure to ADCA ranged from below the limit of detection to 12,000microg/m3. No evidence was found of chronic effects of exposure on pulmonary function, although irritant effects were also found in exposed workers in this facility.
NIOSH-Author; Sampling-methods; Chemical-analysis; Airborne-dusts; Analytical-methods; Azo-compounds; Amides; Plastic-products; Air-sampling; Chromatographic-analysis; Particulate-dust; Skin-irritants; Pulmonary-system-disorders
S.H. Ahrenholz, Division of Surveillance Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226
American Industrial Hygiene Association Journal