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Mutagenicity assessment of airborne particles from three polyurethane foam manufacturing facilities.
Ong M; Stewart J; Whong Z; Boeniger M
Am J Ind Med 1987 Apr; 11(4):475-483
A study of the mutagenic potential of airborne particulates from polyurethane foam manufacturing was conducted. Airborne particles and gases and vapors were collected at three polyurethane foam manufacturing facilities (SIC-3079). Two facilities produced molded foam items for the automobile industry. The third produced slab foam stock from which finished products such as carpet cushioning and automobile padding were made. The particulates were collected on glass fiber filters and the gases on sorbent cartridges. The samples were extracted with methylene-chloride, followed by acetone plus methanol. The extracts were assayed for mutagenic activity using the Ames/Salmonella system. Strains (TA-98) and (TA-100) with or without metabolic activation by rat liver S9 mix were utilized. The particulate samples were mutagenic to (TA-98) with and without S9 activation. The mutagenicity was significantly higher with S9 activation. Some samples from the hot wire area of the slab foam manufacturer were weakly mutagenic to (TA-100) in the presence of S9 mix. None of the samples collected on sorbent cartridges showed any mutagenic activity. The authors conclude that solvent extractions of airborne particles collected from polyurethane manufacturing facilities are mutagenic. The patterns of mutagenicity are similar, suggesting that the chemicals responsible for mutagenic activity are mostly promutagens which induce frameshift mutations.
NIOSH-Author; Polymers; Mutagenesis; Air-samples; Microbial-test-systems; Bioactivation; Airborne-particles; Bioassays; Plastic-products; Workplace-studies; Author Keywords: polyurethane manufacturing industry; toluene diisocyanate; workplace environment; mutagenicity; airborne particles; Salmonella typhimurium
Dr. Tong-man Ong, NIOSH, Microbiology Section, 944 Chestnut Ridge Road, Morgantown, WV 26505-2888
Issue of Publication
American Journal of Industrial Medicine
Page last reviewed: May 5, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division