The effects of sulfur dioxide on pulmonary function in healthy nonsmoking male subjects aged 55 years and older.
Rondinelli-RC; Koenig-JQ; Marshall-SG
Am Ind Hyg Assoc J 1987 Apr; 48(4):299-303
The effects of respired sulfur-dioxide (7446095) on pulmonary function in 10 nonsmoking healthy male volunteers aged 55 to 73 years were examined. Subjects were exposed to 1.0 or 0.5 parts per million (ppm) sulfur-dioxide in sodium-chloride (NaCl) droplet aerosol or to aerosol alone, while at rest for 20 minutes and during moderate exercise on a treadmill for 10 minutes. The NaCl droplet aerosol was at a particle mass concentration of 1mg/m3. Respiration of sulfur-dioxide at a dose of 1.0 part per million significantly enhanced the reduction in forced expiratory volume over that observed following respiration of NaCl aerosol only. Thus sulfur- dioxide at the level of 1ppm produced a decrement in forced expiratory volume beyond the exercise induced bronchoconstriction following normal saline exposure. When these data were compared to an historical profile obtained from healthy adolescent males, a moderate increase in sensitivity to respired sulfur-dioxide was observed. Subjects filled out a symptom rating form to record subjective reactions immediately after exposure, on the test day and on the next day. There were no consistent differences in symptom rating between NaCl aerosol exposure and sulfur-dioxide in NaCl aerosol.
NIOSH-Publication; NIOSH-Grant; Humans; In-vivo-studies; Acute-exposure; Environmental-exposure; Air-contamination; Air-quality; Age-factors
Special Populations; Work Environment and Workforce
American Industrial Hygiene Association Journal
Environmental Health University of Washington Environmental Health Dept Seattle, Wash 98195