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Experimentally induced osteonecrosis in animals.

Walder DN
Dysbarism-related osteonecrosis: proceedings of a symposium on dysbaric osteonecrosis. Beckman EL, Elliott DH, eds. Cincinnati, OH: U.S. Department of Health, Education, and Welfare, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, DHEW (NIOSH) Publication No. 75-153, 1974 Jan; :113-116
The effect of mechanically interfering with the blood supply to the femoral head in sheep was investigated to gain further understanding of the etiology of osteonecrosis in humans subjected to decompression stress. Eighteen sheep underwent surgery during which the lateral or superior epiphyseal vessels to one femur and its capsule were cut. After the operation, the femoral head was supplied only by a small leash of vessels, the medial or inferior epiphyseal vessels, with perhaps a few vessels passing through the ligamentum teres as well. Two or three months following the interruption of the blood flow to the bone, eight of the sheep developed clear cut radiologically detectable lesions in the femoral head of the side operated upon. Six others developed signs that may or may not have indicated lesions and four others developed no abnormalities. The lesions were followed for as long as 19 months in some cases, and they appeared to regress, not worsen, as time went on. Some lesions repaired themselves completely. The case of one man is cited as an example of bone repair in humans. On autopsy, a compressed air worker who had died of decompression sickness showed a typical osteonecrosis lesion, and a much larger area with new bone laid over dead trabeculae. This indicated that a larger area of bone than was evident on radiographs had been involved in the osteonecrotic process and had experienced natural repair.
Laboratory-animals; Humans; Bone-disorders; Skeletal-system-disorders; Skeletal-stress; Hypobarism; Decompression-sickness; Blood-vessels; Caisson-disease
Publication Date
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Conference/Symposia Proceedings
Beckman EL; Elliott DH
Fiscal Year
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Dysbarism-related osteonecrosis: proceedings of a symposium on dysbaric osteonecrosis
Page last reviewed: November 6, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division