Toxicokinetics and molecular interaction of [14C]-formaldehyde in rats.
Upreti-RK; Farooqui-MY; Ahmed-AE; Ansari-GA
Arch Environ Contam Toxicol 1987 May; 16(3):263-273
The toxicokinetics of intraperitoneally administered formaldehyde (50000) were investigated in male Sprague-Dawley-rats given single injections. Some cholinomimetic signs, including reddening of the nose, salivation, and lacrimation, occurred in rats within 20 to 30 minutes following a 72 milligram formaldehyde dose. For about 4 hours, the animals remained sluggish and dull, returning to normal in 4 to 6 hours. All animals experienced mild diarrhea after 6 hours which disappeared by the end of 12 hours. Ten percent of the carbon-14 (C-14) labeled dose was recovered in the expired air during the first hour as carbon-dioxide. After 72 hours had passed, 41 percent of the administered dose had been expired. The highest levels of C-14 in the blood were found in the first hour. Plasma C- 14 levels decreased consistently over time. Red blood cells showed a decrease until 6 hours, followed by a significant elevation. High concentrations of radioactivity were noted in the liver, kidney and gastrointestinal tract during the first 6 hours. Subsequently a gradual decline with time was noted. In the first 3 hours, significant concentrations were noted in the spleen, thymus, lung, and trachea. An indiscriminate registration of C-14 activity was noted in all subcellular fractions of various tissues examined, although somewhat higher levels were noted in microsomes and nuclear fractions. Radioactivity was also noted in phospholipids. The authors conclude that exhalation is the primary route of formaldehyde elimination, and they state that these findings suggest a molecular basis for cellular changes which follow formaldehyde exposure.
NIOSH-Publication; NIOSH-Grant; Aldehydes; Laboratory-animals; In-vivo-studies; Metabolic-study; Tissue-distribution; Kinetics; Toxic-effects
Human Biol Chem and Genetics University of Texas Med BR Dept of Human Biol Chem&gene Galveston, Tex 77550-2774
Archives of Environmental Contamination and Toxicology
University of Texas Medical Branch, Galveston, Texas