Theories of electrostatic lung deposition of inhaled aerosols.
Ann Occup Hyg 1985 Apr; 29(2):219-227
The fundamental physics of charged particle deposition are reviewed. Also developed is a computational model to predict the amount and site of deposition in the human respiratory tract under various conditions. Particle charge can lead to a significant increase in aerosol deposition in the lung. At low concentrations, for environmental aerosols, the deposition increase primarily results from the presence of the image force acting on the particle, and the sign of charge does not affect deposition. In most cases, particle charge level is moderate and therefore conventional mechanisms control the amount of deposition. A charge level thus exists for each particle size below which the effect of particle charge on deposition is not significant. The values of this charge level are calculated for particles in the size range where deposition is dominated by sedimentation. As derived, the theory presented applies only to spherical, compact, or isometric particles. For fibrous particles carrying a charge, interaction between the particle and the airway wall may affect the particle and its deposition. Impaction, sedimentation, and interception depositions of these particles are thus different due to changes in torque and force on the particle.
NIOSH-Publication; NIOSH-Grant; Inhalants; Respiratory-irritants; Particulate-dust; Lung-irritants; Particulate-sampling-methods; Aerosol-particles; Aerosol-sampling
Annals of Occupational Hygiene
State University of New York at Buffalo, Buffalo, New York