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Results of testing fifteen glycol ethers in a short-term in vivo reproductive toxicity assay.

Schuler RL; Hardin BD; Niemeier RW; Booth G; Hazelden K; Piccirillo V; Smith K
Environ Health Perspect 1984; 57:141-146
A screening bioassay of the reproductive effects of glycol ethers was conducted in mice. Pregnant CD-1-mice were administered 15 glycol ethers orally on days seven through 14 of gestation at concentrations ranging up to 11270mg/kg. The potential of the compounds for causing adverse reproductive effects was evaluated by determining pup survival in-utero, pup perinatal survival, and postnatal survival (number of live pups per litter, number of dead pups per litter, and pup survival up to 2.5 days of age), and pup weights at birth and 2.5 days of age. Maternal mortality was recorded. Maternal mortality ranged up to 41 percent, the largest number of deaths occurring after treatment with diethylene-glycol- dimethyl-ether (111966). Mice treated with ethylene-glycol- monomethyl-ether (109864) (EGME), ethylene-glycol-monoethyl-ether (110805) (EGEE), ethylene-glycol-dimethyl-ether (110714), and triethylene-glycol-dimethyl-ether (112492) produced no litters. Mice treated with ethylene-glycol (107211), ethylene-glycol- monobutyl-ether (111762), ethylene-glycol-diethyl-ether (629141) (EGdiEE), and diethylene-glycol-monomethyl-ether (111773) (diEGME) showed significant reductions in viable litters. Ethylene-glycol and EGdiEE reduced the number of live pups per litter, and pup birth weight and weight gain. diEGME significantly reduced the number of live pups per litter and pup survival. Diethylene-glycol-diethyl- ether (112367) significantly increased the number of dead pups per litter and reduced pup birth weights. Diethylene-glycol-dibutyl- ether (112732) increased the number of dead pups per litter. Diethylene-glycol (111466) reduced pup weight gain. Triethylene- glycol (112276) and diethylene-glycol-monoethyl-ether (111900) reduced mean pup birth weights. The authors note that, on the basis of their results, they cannot definitely label a given compound as safe or unsafe and that the compounds should be tested further, especially EGME, EGEE, and EGdiME which are known to be teratogenic in other studies.
NIOSH-Author; Bioassays; Organic-chemicals; Reproductive-effects; Glycols; Transplacental-exposure; Toxic-effects; Embryotoxicity; In-vivo-studies; Laboratory-animals
111-96-6; 109-86-4; 110-80-5; 110-71-4; 112-49-2; 107-21-1; 111-76-2; 629-14-1; 111-77-3; 112-36-7; 112-73-2; 111-46-6; 112-27-6; 111-90-0
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Journal Article
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Environmental Health Perspectives
Page last reviewed: September 2, 2020
Content source: National Institute for Occupational Safety and Health Education and Information Division