Occupational Diseases, A Guide to Their Recognition, Revised Edition. Key MM, Henschel AF, Butler J, Ligs RN, Tabershaw IR, eds., Cincinnati, OH: National Institute for Occupational Safety and Health, 1977 Jun; :453-463
Pesticide compounds used in agriculture, pest control industries, and public health are discussed, and information on their chemical nature, use, signs and symptoms associated with toxic exposures, clinical recognition, exposure limits, and treatment is provided. Chemicals discussed include organophosphates, carbamates, chlorinated hydrocarbons, bipyridyls, rodenticides, fungicides, herbicides, fumigants, and miscellaneous insecticides. To determine the source of exposure, the physician must be aware of both occupational and nonoccupational aspects of an individual's activities. Correct diagnosis is predicated on a history of exposure compatible with time dose relationships, clinical manifestations, and laboratory confirmation. In cases of severe poisoning, initial diagnosis and treatment must depend on clinical diagnosis since there is often insufficient time to wait for the results of laboratory tests. The nature of the compound and its formulation, and possibly individual variations, are the factors which influence the clinical appearance of an intoxication and the toxic dose of the substance.