Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-541 1981 Apr; :1-13
Information on potential occupational hazards from exposure to carbonyl-fluoride (353504) was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. Production of carbonyl-fluoride was assumed to be less than 10,000 pounds annually. Potential exposure to carbonyl- fluoride occurs as a result of the thermal decomposition of polytetrafluoroethylene (PTFE) in air. Effects of acute exposure in animal studies included extreme malaise and weakness which preceded death. Subchronic exposure studies with PTFE pyrolysis products revealed pathologic changes in the respiratory tracts and livers of exposed animals. Exposure of rats to pyrolysis products containing 52, 43, 29, 25, and 9 parts per million carbonyl-fluoride increased the fluoride in urine and decreased body weights by 30 percent. Succinic-dehydrogenase activity was increased in the lungs but not in the kidneys. Changes were also noted in the blood leukocyte composition, but not in total count. Protein, glucose, ketones, and occult blood appeared in the urine following exposure. No information was available concerning chronic exposures, carcinogenicity, mutagenicity, teratogenicity, or reproductive effects.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-541