Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-521 1981 Mar:15 pages
Information on potential occupational hazards from exposure to benzoin (119539) was reviewed. Topics discussed included chemical and physical properties, production, uses, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. The annual production of benzoin is approximately 90,000 pounds per year with an historical growth rate of about 6 percent per year. The compound is used in the production of polyester resin wetting and emulsifying agents; stilbestrol products; medicines; ether derivatives; personal use products such as perfumes, creams, and cosmetics; and as a synthetic flavoring agent. Studies have shown that acute oral exposure causes labored respiration, depression, dyspnea, urine stains, ataxia and unkempt fur in rats. In addition, mice also demonstrated enlarged lymph nodes in both males and females and enlarged spleens in males. Toxic effects in mice and rats fed diets containing benzoin for 13 weeks included interstitial nephritis, discoloration of the liver, green tinged kidney cortices, scattered vacuolated hepatocytes, and depression in weight gain. In carcinogenesis studies, the incidence of lymphomas and leukemia in dosed male rats increased with dose level, but not significantly. Mice demonstrated a significant increase in the incidence of lymphomas and leukemias at low dose levels. Bioassays have indicated that benzoin is not carcinogenic to male or female F344-rats or B6C3F1-mice. No evidence of mutagenicity, teratogenicity, or reproductive effects was found in animal studies. Allergic contact dermatitis has been reported in humans.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-521