Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-519 1981 Mar:22 pages
Information on potential occupational hazards from exposure to adipic-acid (124049) was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposure, and biological effects. Production of adipic-acid was 1.8 million pounds in 1979; most of this was used in the production of nylon-66 fibers. Other uses included the production of nylon-66 resins, nylon-66 plastics, as a hexamethylenediamine precursor, in polyurethane resins and plasticizers, and as a food additive. To a much smaller extent adipic-acid was used in insecticides, adhesives, tanning and leather dyes, textile printing, and textile softening. Administration of adipic acid to experimental animals has produced patchy livers, irritation of organs directly exposed, hemorrhagic lungs and symptoms of acidosis. A median lethal dose of 940mg/kg was established for adult male rats. Subchronic exposures in rats produced symptoms of toxicity including depression, dyspnea, ataxia, and convulsions. No significant evidence for carcinogenicity has been reported nor has there been any finding of mutagenicity or teratogenicity or any reproductive effects. No evidence of toxicity was found on oral administration of 100mg/kg adipic-acid per day to human subjects.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-519