Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-526 1981 Mar:33 pages
Information on potential occupational hazards from hemimellitene (526738), pseudocumene (95636), and mesitylene (108678) was reviewed. Topics discussed included chemical and physical properties, production, use, manufacturers and distributors, manufacturing processes, occupational exposures and biological effects. Studies indicated that these compounds enter the body primarily through inhalation but can also be absorbed through the skin. Central nervous system depression, irritation of mucous membranes, and respiratory irritation have been caused by exposure to these chemicals in experimental animals. Pneumonitis, edema, tissue necrosis and hemorrhage of the lungs have been brought about by the aspiration of liquid trimethylbenzenes. The use of an organic solvent containing 50 percent pseudocumene, 30 percent mesitylene, and traces of hemimellitene caused hypochromic anemia, hemopoietic disturbances, chronic asthmatic bronchitis, and central nervous system depression in humans. Rabbits receiving subcutaneous injections of mesitylene and pseudocumene experienced temporary leukopenia and thrombocytopenia plus a reduction in erythrocytes. Hemimellitene was used in the making of polyfunctional acids and miscellaneous chemical syntheses. The major use for this chemical was in automobile gasoline. Pseudocumene was used in the production of trimellitic-anhydride and pseudocumidene, a dye intermediate. It was also present in most automobile fuels. Mesitylene was used in paint thinners and solvents, in the production of trimesic-acid, and in stabilizers for plastics.
Center for Chemical Hazard Assessment, Syracuse Research Corporation, Syracuse, New York, Report No. SRC TR 81-526