Information on potential occupational hazards from metallocenes was reviewed. Topics discussed included chemical and physical properties, chemical structure, production volumes, uses and manufacturing process. A list of manufacturers was developed. More detailed profiles were presented for ferrocene (102545), acetyl- ferrocene (1271552) and ethyl-ferrocene (1273898). Ferrocene has been used as a smoke suppressant for rigid polyurethane and rigid PVC, an additive in fuel oils, an antiknock agent, a catalyst, and an ingredient in coatings for missiles and satellites. High temperature lubricants and intermediates for high temperature polymer formation also use ferrocene. Studies indicated that ferrocene is slightly to moderately toxic in animals with rodent oral median lethal doses (LD50s) greater than 1000mg/kg being reported. Cirrhosis of the liver and testicular hypoplasia in dogs were reported to be caused by subchronic oral exposures. Acetyl- ferrocene appeared to be more toxic than ferrocene in the only study performed thus far. Data on carcinogenicity, mutagenicity and teratogenicity of acetyl-ferrocene were not available. No information on the biological effects of ethyl-ferrocene was presented.
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