Regional alterations in serotonin metabolism induced by oral exposure of rats to polychlorinated biphenyls.
Seegal-RF; Brosch-KO; Bush-B
Neurotoxicology 1986 Jan; 7(1):155-166
Adult male Wistar derived rats were given single oral doses of corn oil or polychlorinated-biphenyls (PCBs) in corn oil, at levels calculated to yield a final dose of either 500 or 1000 milligrams of total PCBs per kilogram of body weight. Levels of PCBs were consistently higher in brains of animals exposed at the higher dose level. Levels of PCBs in the brains of animals receiving half the dose were higher than half the level of PCBs in brains of animals receiving the full dose, and the authors conclude that PCBs move into the brain by way of a saturable transport system. The single dose was able to significantly alter serotonin (5-HT) concentrations and metabolism in most of the brain areas that were examined. This indicated that neurochemical changes were evident following PCB exposure in the adult animal. While PCB levels in the brain regions were able to be determined, it was not possible in most sections to correlate changes in 5-HT concentrations or in 5-hydroxyindole- acetic-acid to 5-HT ratios with concentration changes of PCBs. The magnitude of the changes induced in 5-HT concentrations by PCB exposure are expected to cause changes in behavior, with particular attention to locomotor activity, of the animal so treated. The authors state that these findings are also reversible and appear to be dependent on the presence of PCBs in the nervous tissue.
NIOSH-Publication; NIOSH-Grant; Laboratory-animals; Metabolic-study; Central-nervous-system; Neurotoxicology; Neuropathology; Chemical-manufacturing-industry; Electrical-industry; Environmental-contamination; Chlorinated-biphenyls
N Y St Dept of Health Empire State Plaza Albany, NY 12237