Surveillance of parental employment and spontaneous abortion.
Kline J; Stein Z; Hatch M; Hutzler M; Lai A; Pantel-Silverman J
Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, 1982 Oct; :1-200
Associations between the chromosomal characteristics of the aborted conceptus and parental employment were sought using data from a case control study of spontaneous abortions in New York City. Two associations did emerge from the data as potentially sound. Maternal employment in a cleaning service occupation appeared associated strongly with chromosomally normal abortions, and paternal employment in a hospital or nursing facility was associated with monosomy-X. While cleaning service work was not significantly associated with chromosomal abnormality, the odds ratio for abnormality was raised slightly and the 95 percent confidence interval included the odds ratio observed in association with chromosomally normal abortion. Thus, it is not certain that the effect noted is indeed specific to chromosomally normal abortion only. The association of paternal work in a hospital or nursing facility with monosomy-X was a strong association. However, the occupational group most likely to account for the effect could not be identified positively, nor the presumed exposure causing the problem. No association was found between maternal work during pregnancy and chromosomally normal abortion. Maternal employment in a hospital or nursing facility did not appear to be associated with spontaneous abortion of any type. Maternal factory work before pregnancy was not associated with chromosomally normal abortion.
NIOSH-Contract; Contract-210-81-5002; Chromosome-damage; Reproductive-hazards; Reproductive-effects; Reproductive-system-disorders; Workplace-studies
National Institute for Occupational Safety and Health