Effects of elevated lead and cadmium burdens on renal function and calcium metabolism.
Greenberg-A; Parkinson-DK; Fetterolf-DE; Puschett-JB; Ellis-KJ; Wielopolski-L; Vaswani-AN; Cohn-SH; Landrigan-PJ
Arch Environ Health 1986 Mar; 41(2):69-76
A group of 38 industrial workers aged 33 to 77 years, with an occupational exposure to lead (7439921) (Pb) and cadmium (7440439) (Cd) ranging from 11 to 37 years, were tested to determine body burden of the two metals, renal function and metabolism of calcium (Ca), phosphorus (P), and vitamin-D. X-ray fluorescence spectrometry of the tibia revealed an increased body burden of Pb in 58 percent of the men, and following infusion of Ca- ethylenediaminetetraacetic-acid, urinary Pb levels were increased in 36 percent. Neutron activation analysis demonstrated high levels of Cd in the liver and kidney of 31 percent of the men, while creatinine clearance was normal in all individuals tested. Twelve of 23 men (52 percent) in whom urine osmolality could be evaluated presented impaired maximum urinary concentrating ability. Serum calcium levels were normal in all men, but eight of 37 (22 percent) had hypercalciuria and two had low levels of vitamin-D in the serum. One man was affected by hyperuricemia, two had proteinuria, three had high excretion of beta-2-microglobulin and one had low urinary acidifying ability. Chi square analysis failed to demonstrate a significant correlation between the prevalence of hypertension and metal body burden. The authors conclude that the findings are indicative of a modest prevalence of renal dysfunction in the group of workers studied.
NIOSH-Publication; NIOSH-Contract; Contract-210-81-5013; NIOSH-Grant; NIOSH-Author; Grants-other; Lead-compounds; Cadmium-compounds; Kidney-function; Kidney-disorders; Humans; Occupational-exposure; Hematology; Long-term-exposure
Medicine University of Pittsburgh 1191 Scaife Hall Pittsburgh PA 15217
Other Occupational Concerns; Grants-other
Archives of Environmental Health
University of Pittsburgh at Pittsburgh, Pittsburgh, Pennsylvania